Control of Glucose after Injury

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Glucose, insulin and other plasma metabolites shortly after injury.

A statistical study was made of measurements within 3 h of injury on 533 patients grouped by injury severity using ISS. A scoring system was also used that took account of the number of injuries. Widely accepted hypotheses about the development of hyperglycaemia were not supported. There was evidence of inhibition of glucose metabolism ('insulin resistance'), but none for any particular mechani...

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Glucose and oxygen metabolism after penetrating ballistic-like brain injury

Traumatic brain injury (TBI) is a major cause of death and disability in all age groups. Among TBI, penetrating traumatic brain injuries (PTBI) have the worst prognosis and represent the leading cause of TBI-related morbidity and death. However, there are no specific drugs/interventions due to unclear pathophysiology. To gain insights we looked at cerebral metabolism in a PTBI rat model: penetr...

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Normal glucose enhances neuronal regeneration after lidocaine-induced injury.

BACKGROUND Local anaesthetics exhibit direct neurotoxic effects on neurones. Numerous studies have investigated the factors that may reverse this neuropathology, but the effects of glucose conditions on neuronal regeneration after lidocaine-induced injury have not been examined by observing living neurones. The present study investigated the effects of different glucose conditions on neurite le...

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Does tight glucose control prevent myocardial injury and inflammation?

Hyperglycemia has been postulated to be cardiotoxic. We addressed the hypothesis that uncontrolled blood glucose induces myocardial damage in diabetic patients undergoing isolated coronary artery bypass graft surgery receiving continuous insulin infusion in the immediate postoperative period. Our primary aim was to assess the degree of tight glycemic control for each patient and to link the deg...

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ژورنال

عنوان ژورنال: The American Surgeon

سال: 2008

ISSN: 0003-1348,1555-9823

DOI: 10.1177/000313480807400303